Clinical Research Using a Neonicitenoid (Capstar, Nitenpyram)

The neonicitenoids target invertebrate specific GABA activated chloride channels in the central nervous system and cause paralysis. Neonicitinoids like Advantage are currently the gold standard for treatment of fleas (arthropods) in dogs and cats. Preliminary data shows that an oral dose of 10-30 mg/kg weekly is safe for the fish used in the study and is effective in eliminating 100 percent of Lernea sp. copepods within seven to ten days of treatment.

MCRI Research Archive